The neuropharmacokinetics of valproate in pentylenetetrazol-kindled conscious epileptic rat hippocampus
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منابع مشابه
Ivabradine Reduces Seizures in Pentylenetetrazol- Kindled Mice
Methods: Forty Mice were randomly allocated into 4 equal groups; control, PTZ, diazepam (4mg/kg) and ivabradine (10 mg/kg) groups. Kindling model was produced by repeated i.p. administration of PTZ (40mg/kg), every other day for 9 days. Repeated PTZ treatment progressively increased the seizure score with the maximum score reached on day 9. Diazepam and ivabradine were administered intraperiton...
متن کاملMontelukast reduces seizures in pentylenetetrazol-kindled mice.
Cysteinyl leukotrienes (CysLTs) have been implicated in seizures and kindling; however, the effect of CysLT receptor antagonists on seizure frequency in kindled animals and changes in CysLT receptor expression after pentylenetetrazol (PTZ)-induced kindling have not been investigated. In this study, we evaluated whether the CysLT1 inverse agonist montelukast, and a classical anticonvulsant, phen...
متن کاملPentylenetetrazol-kindling induced synaptic plasticity in the CA1 region of rat hippocampus
The impact of pentylenetetrazol-induced kindling on the effectiveness of theta pattern primed-bursts (PBs) for the induction of long-term potentiation (LTP) of field excitatory postsynaptic potentials (fEPSP) and population spikes (PS) were investigated in hippocampal CA1 of pentylenetetrazol-kindled rats in vivo. The results showed that shortly after kindling, control animals had normal LTP of...
متن کاملPentylenetetrazol-kindling induced synaptic plasticity in the CA1 region of rat hippocampus
The impact of pentylenetetrazol-induced kindling on the effectiveness of theta pattern primed-bursts (PBs) for the induction of long-term potentiation (LTP) of field excitatory postsynaptic potentials (fEPSP) and population spikes (PS) were investigated in hippocampal CA1 of pentylenetetrazol-kindled rats in vivo. The results showed that shortly after kindling, control animals had normal LTP of...
متن کاملThe involvement of neuronal nitric oxide synthase in the anti-epileptic action of curcumin on pentylenetetrazol-kindled rats.
In this study, it was investigated whether a NO signaling pathway is involved in the anti-epileptic effect of curcumin on pentylenetetrazol (PTZ)-kindled rats. PTZ-kindled rats received different doses of curcumin that were administered intraperitoneally for 24 days. Either a non-selective inhibitor of nitric oxide synthase (NOS) (N-nitro-L-arginine methyl ester (L-NAME)), a selective inhibitor...
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ژورنال
عنوان ژورنال: Biomedical Research
سال: 2004
ISSN: 0388-6107,1880-313X
DOI: 10.2220/biomedres.25.119